Morphology of interstitial cells of Cajal in the gastrointestinal tract of Mongolian gerbil

doi:10.3969/j.issn.0529-1356.2013.01.018

Abstract

Abstract:

Objective To observe the distribution and morphological features of interstitial cells of Cajal (ICCs) in the gastrointestinal (GI) tract of Mongolian gerbil. Methods Whole GI tracts, including stomach, small and large intestines of ten adult Mongolian gerbils were removed and performed for C-kit immunocytochemical staining with whole-mount preparations and cryo-sections. Results c-Kit positive immunoreactivity cells distributed along the entire GI tract. Intramuscular ICC(ICC-IM) cells were only in the fundus of the stomach.Myenteric ICC(ICC-MY) profiels were encountered between the longitudinal and circular muscle layers of the corpus and antrum of the stomach. The density of ICC-IM profiels gradually decreased from the fundus to the antrum. Whereas, ICC-MY profiels gradually increased from the corpus to the antrum. In the small intestine, ICCs were often observed in three regions, i.e. deep muscular plexus ICC(ICC-DMP), ICC-IM and ICC-MY. While in the colon, ICCs were seen as ICC-IM, ICC-MY and Swbmucosal ICC(ICC-SM). Conclusion Mongolian gerbil may be used to research the morphology and function of ICCs.

Key words: Interstitial cells of Cajal, Kit, Gastrointestinal tract , Immunofluorescence, Mongolian gerbil

CLC Number:

R329

LIU Li,SUN Hai-mei,WU Bo,ZHOU De-shan*. Morphology of interstitial cells of Cajal in the gastrointestinal tract of Mongolian gerbil[J]. AAS, 2013, 44(1 ): 93-96.

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